Diabetes Mellitus Is Associated with a Lower Risk of Gout

New meta analysis just released:

Outcomes: Five studies including 863,755 participants were included in our meta-analysis. DM was connected with a lower risk of gout (aRR: 0.66; 95% CI: 0.59 to 0.73) but had a high heterogeneity (I 2 = 89.2%). Metaregression analysis exposed that the kinds of DM were the source of heterogeneity. Subgroup analysis by kinds of DM revealed that the danger of gout was considerably lower in type 1 DM (T1DM) (aRR: 0.42; 95% CI: 0.28 to 0.63) than in type 2 DM (T2DM) (aRR: 0.72; 95% CI: 0.70 to 0.74). When stratified according to gender in DM, sex-specific association was found. The inverse association was observed in males only (aRR: 0.57; 95% CI: 0.43 to 0.77) and not in females (aRR: 0.96; 95% CI: 0.87 to 1.05). Further stratified based on glycated hemoglobin (HbA1c) levels in DM, raised A1C levels were associated with a decreased risk of gout in patients with DM.

Objectives: Although a number of epidemiological studies have investigated the relationship in between diabetes mellitus (DM) and the risk of gout, the results are irregular. We methodically retrospected offered observational research studies to clarify the impact of DM on the risk of gout.

Conclusions: This meta-analysis suggested that DM was related to a lower risk of gout, and the protective result of DM on the threat of gout was stronger in males, T1DM, or DM with high HbA1c levels. More prospective mate research studies are needed to verify these outcomes.

The quality of the included research studies was evaluated utilizing the Newcastle-Ottawa Quality Assessment Scale. The multivariate adjusted relative threats (aRR) and matching 95% confidence intervals (CI) were pooled based on a random-effect model.

More: Diabetes Mellitus Is Associated with a Lower Risk of Gout

DM was associated with a lower danger of gout (aRR: 0.66; 95% CI: 0.59 to 0.73) but had a high heterogeneity (I 2 = 89.2%). Subgroup analysis by types of DM showed that the threat of gout was substantially lower in type 1 DM (T1DM) (aRR: 0.42; 95% CI: 0.28 to 0.63) than in type 2 DM (T2DM) (aRR: 0.72; 95% CI: 0.70 to 0.74). Additional stratified based on glycated hemoglobin (HbA1c) levels in DM, raised A1C levels were associated with a minimized danger of gout in patients with DM.
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