” Revive was founded on the facility of finding brand-new uses for known drugs, and we are broadening on our rich item portfolio to target transmittable diseases such as the coronavirus illness or COVID-19,” stated Michael Frank, Revives Chief Executive Officer. “Revive has a history in the medical advancement with Bucillamine in the treatment of intense gout flares and cystinuria, and we will advance our efforts in restoring and checking out new usages of Bucillamine for unmet medical requirements.”
TORONTO, March 20, 2020 (WORLD NEWSWIRE)– Revive Therapies Ltd. (” Revive” or the “Business”) (CSE: RVV), a life sciences business, is delighted to reveal that it is checking out making use of the drug Bucillamine as a prospective novel treatment for contagious diseases including influenza and the coronavirus illness (COVID-19). The Business has actually requested a provisionary patent with the U.S. Patent and Trademark Office entitled “Use of Bucillamine in the Treatment of Contagious Diseases” (Serial No. 62/991,996).
Restore has explored making use of Bucillamine in the treatment of severe gout flares and has completed a Phase 2 research study in the U.S. under its Investigational New Drug (” IND”) application that was accepted by the U.S. Food and Drug Administration (” FDA”). The Company checked out the usage of Bucillamine in the treatment of cystinuria where it has actually received FDA orphan drug status and its IND was accepted by the FDA to perform a Phase 2 research study in the U.S.
Scientific Rationale for the Investigation reasoning Bucillamine to Treat Infectious Diseases including Influenza transmittable COVID-19
Bucillamine (N-( mercapto-2-methylpropionyl)- l-cysteine), which has a widely known security profile and is recommended in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years, is a cysteine derivative with 2 thiol groups that is 16-fold more powerful than NAC as a thiol donor in vivo, providing it greatly remarkable function in bring back glutathione and for that reason greater potential to avoid intense lung injury during influenza infection.8 Bucillamine has also been shown to avoid oxidative and reperfusion injury in heart and liver tissues8 and is extremely cell permeable for effective shipment into cells.8,9 Bucillamine has unrealized potential for the treatment of influenza with both proven safety and tested system of action similar to that of NAC, but with much higher effectiveness, reducing the previous barriers to utilizing thiols therapeutically. It is likewise sensible to hypothesize that comparable processes connected to ROS are involved in severe lung injury throughout nCov-19 infection, potentially justifying the investigation of bucillamine as an intervention for COVID-19.
Revive is establishing an item and scientific advancement strategy intending to unlock the complete capacity of Bucillamine. The Company will announce its initiatives as they unfold.
Current antiviral interventions for influenza have actually displayed modest efficacy, particularly in improving death in at-risk populations, such as the elderly.1,2 Novel antivirals have actually been pestered by poor oral bioavailability and lack of efficacy when not provided early.1 This is since these drugs mostly act to prevent the early processes of virus binding to cells or viral duplication.2 Thiols, especially N-acetylcysteine (NAC), with antioxidant and lowering activity have been examined as reliable treatments that abrogate the capacity for influenza to cause severe illness.3,4,5 Restoration of glutathione, the major intracellular thiol antioxidant, is a vital functional activity of NAC.6 Reactive oxygen types (ROS) generation during influenza virus infection worsen harmful inflammation and configured death of epithelial cells.7 Studies in human cells and animal designs have revealed that NAC works to prevent severe lung injury brought on by influenza virus infection through inhibition of these ROS-mediated systems.4,7 NAC has actually been examined scientifically and found to significantly attenuate medical signs connected with influenza infection, specifically in elderly at-risk patients.5 While NAC is quickly used up by cells and has low toxicity, scientific efficacy has actually required long-term and high-dose administration since of modest relative effectiveness, limiting its clinical applicability.
Revive is a company focused on the research, advancement and commercialization of unique psychedelic and cannabinoid-based life sciences products and drug repurposing for infectious illness. With its recent acquisition of Psilocin Pharma Corp., Revive will advance Psilocybin-based therapies in various diseases and disorders and will focus on advancement efforts to take benefit of several regulatory rewards awarded by the FDA such as Orphan Drug, Fast Track, Breakthrough Therapy and Rare Pediatric Disease classifications. The Company is likewise checking out the usage of Bucillamine for the potential treatment of infectious illness.
1. Muthuri SG, Venkatesan S, Myles PR et al. Effectiveness of neuraminidase inhibitors in minimizing mortality in patients confessed to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of private participant data Lancet Respir Med. 2014 May; 2( 5 ):395 -404. doi: 10.1016/ S2213-2600( 14 )70041-4.
2. Duwe S. Influenza infections– antiviral therapy and resistance.
3. Zhang RH, Li CH, Wang CL et al. N-acetyl-l-cystine( NAC) secures versus H9N2 swine influenza virus-induced acute lung injury. Int Immunopharmacol. 2014 Sep; 22( 1 ):1 -8. doi: 10.1016/ j.intimp.2014.06.013.
Ungheri D, Pisani C, Sanson G et al. Protective impact of n-acetylcysteine in a model of influenza infection in mice.
5. De Flora S, Grassi C, and Carati L. Attenuation of influenza-like symptomatology and enhancement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J 1997; 10: 1535– 1541 DOI: 10.1183/ 09031936.97.10071535.
The Basics of Thiols and Cysteines in Redox Biology and Chemistry. Free Radic Biol Med. 2015 Mar; 0: 148– 157.
7. Mata M, Morcillo E, Gimeno C, Cortijo J. N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory conciliators in alveolar type II epithelial cells contaminated with influenza infection A and B and with respiratory syncytial infection (RSV). Biochem Pharmacol. 2011 Sep 1; 82( 5 ):548 -55. doi: 10.1016/ j.bcp.2011.05.014.
Bucillamine: a potent thiol donor with several clinical applications. Cardiovasc Drug Rev. 2003 Summer; 21( 2 ):77 -90.
9. Sagawa A, Fujisaku A, Ohnishi K et al. A multicentre trial of bucillamine in the treatment of early rheumatoid arthritis (SNOW study). Mod Rheumatol. 2011 Jun; 21( 3 ):251 -7. doi: 10.1007/ s10165-010-0385-4.
Restore is a business focused on the research study, advancement and commercialization of novel psychedelic and cannabinoid-based life sciences items and drug repurposing for transmittable illness. Restores technology is being advanced to fill the medical needs for disorders and illness such as discomfort, inflammation, and injury care. Revives cannabinoid pharmaceutical portfolio focuses on unusual inflammatory locations such as liver illness. With its recent acquisition of Psilocin Pharma Corp., Revive will advance Psilocybin-based therapeutics in various diseases and conditions and will focus on development efforts to take advantage of several regulative incentives awarded by the FDA such as Orphan Drug, Fast Track, Breakthrough Therapy and Rare Pediatric Disease designations. The Company is also checking out the use of Bucillamine for the prospective treatment of infectious illness.
- Quercetin with Bromelain - Experience the power of a more natural type of daily supplement with a plant-based antioxidant that brings many benefits like joint support for tired joints and muscles
- Healthy Kidney Support Supplement - Get the most out of our daily uric acid supplement that features chanca piedra which is known to boost kidney health and function by balancing your uric acid levels
- A Naturally Powerful Formula - Our daily uric acid supplement features a range of essential ingredients such as vitamin b6 and citric acid as well as balancing ingredients like celery seed extract
- Uric Acid Flush Antioxidant - Our natural ingredients-based uric acid helps joint support and maintains uric acid production in a normal range while also metabolizing excess uric acid in the body
- Natures Craft Quality - Here at Natures Craft we have your needs in mind which is why all of our supplements are 3rd party tested for potency and formulated in the United States by GMPc laboratories
- Audible Audiobook
- David Whitehead (Author) - Jerry Wright (Narrator)
- English (Publication Language)
- 04/21/2021 (Publication Date) - Silk Publishing (Publisher)
- LIVE LIVELY – Don’t let discomfort ruin your day. Ease joint pain and enjoy activities with Mt. Angel Vitamins! Go-Out uric acid cleanse provides sustained relief so you can get back on your feet!
- IMPROVE & MOVE – Sick of stiffness? Help restore joint flexibility with black and tart cherry extract, celery seed extract, bromelain, and turmeric root. Go with go out capsules formulated with ingredients known to reduce inflammation.
- GO WITH THE FLOW – By lowering uric acid levels, your go out relief capsules are known to fortify healthy circulation and blood pressure, protecting muscles and joints from damage.
- SIMPLE SOLUTION – Enjoy a supplement that works with your schedule! To free yourself from pain, just take 1 of your 90 inflammation relief capsules twice daily. Support has never been so simple!
- OUR PROMISE – At Mt. Angel Vitamins, we take pride in our capsules’ quality. We ensure your positive experience with restorative results from personally crafted and tested, non-GMO supplements!
- Jones, Dr Ben (Author)
- English (Publication Language)
- 260 Pages - 06/02/2022 (Publication Date) - Birch Briar Media (Publisher)
- Immediate, Lasting & Quick Relief: Did you know that our unique pain relief cream is preferred by those dealing with inflammation, pain and discomfort related to flare-ups? Numerous All Natural pain relievers go to work to reduce inflammation, provide soothing relief and get you back on your feet!
- Non-Greasy, Non-Staining & Fast Absorbing: Arnica gel cream with a refreshing mint scent. Within minutes, the cream is absorbed and the scent is vanished. Get back to your normal life!
- Made In The USA: Manufactured and Packaged in the USA in a GMP Approved Facility for Purity and Potency
- Natural Ingredients: Include Arnica Extract, Tea Tree Oil, Ilex Leaf Extract, Aloe, vitamins E & B6 and MSM.
- Money Back Guarantee: We stand behind our Therapeutic Pain Relief Cream 100% and are sure you are going to love it! If you are less than 100% Satisfied with our product, for ANY reason, we will refund your money in full with no questions asked. What do you have to lose? Buy Now!
- BOTHERS, BE GONE – Never fear when flare-ups rear. Find support in Mt. Angel Vitamins! Your Go-Out Extra Strength uric acid cleanse has ingredients known to help minimize joint inflammation attacks so you can stay active!
- LOOSE & LIVING – Stiffness won’t stop you. Help restore joint flexibility with your capsules’ powerful formula of cherry extracts, celery seed extract, boswellia, and more!
- ALL-AROUND AID – It’s time to get back on your feet! By reducing uric acid, your gout relief supplements are known to relieve joint pain, fortify healthy circulation, and regulate blood pressure!
- THE EASIEST ESSENTIAL – With your joint-support supplement, a simple routine brings pain-saving results. For immediate relief, take 1 of your 60 capsules twice daily, with a meal.
- OUR PREMIUM PROMISE – Combat discomfort with Mt. Angel Vitamins! We ensure your positive experience with restorative results from personally crafted and tested, non-GMO supplements!
- Amazon Kindle Edition
- Cicciarello Andrews MEd RD LD, Lisa (Author)
- English (Publication Language)
- 218 Pages - 03/17/2020 (Publication Date) - Rockridge Press (Publisher)
- WHY USE A LIQUID TREATMENT? – Research indicates that liquid supplements are more easily absorbed into the body. With an average absorption rate of better than 90% vs. pills at 10-15%, doesn’t it make sense that a liquid can control uric acid better and is the best alternative? Pills using the best of ingredients are simply less effective for relief.
- PROVEN RESULTS – As a naturopathic remedy using only natural and organic ingredients, we addressed the root causes of uric acid buildup, kidney function and circulation. With proven ingredients that address kidney function, inflammation, pain, circulation, and many other health specific issues that take place to create the imbalance of uric acid in the body, these natural remedies are for you. Uric Acid Complete is used both during the course of an attack and as a preventative measure.
- A COMPLETE ALTERNATIVE – With both Organic and Kosher certifications, we use only the highest concentration and quality of ingredients. We use more than 35 ingredients, 3 times more than any comparable product, to help reduce inflammation, increase circulation, cleanse and flush out infection, and rebalance Ph, mineral and uric acid levels. With our 100% SATISFACTION GUARANTEE, you can feel safe that you are making the best choice in a proven and natural uric acid reducer.
- MADE IN THE USA! USDA Organic and OU Kosher Certified.
- ADVANCED URIC ACID SUPPORT Uricel is the premier natural supplement to help support your uric acid levels and get you back on the road to a healthier you!
- 6 PREMIUM URIC ACID SUPPORT INGREDIENTS Chanca Piedra, Tart Cherry, Celery Seed, Turmeric, Yucca & Devils Claw help support your uric acid levels fast!
- GREAT TASTING & EASY TO USE! Our customers are amazed at how good this all-natural formula tastes, and it’s as simple as squeezing a dropper on your tongue - no clumsy pills, no water necessary!
- ALCOHOL-FREE LIQUID FORMULA: Crafted with our advanced extraction process, our liquid formulas are brewed and macerated with an alcohol-free cold-extraction process. Most liquid formulas are made with a warm alcohol extraction that can burn the delicate ingredients and render them less effective.
- INGREDIENTS FROM NATURE: We prioritize ingredients sourced from organic and wildcrafted herb farms so your health gets the best nature has to offer. And instead of cramming all these ingredients in a capsule that was thrown together somewhere in China, Uricel is crafted under the guidance of a trained herbalist.
- Kamveris MS RD LDN, Sophia (Author)
- English (Publication Language)
- 194 Pages - 02/05/2019 (Publication Date) - Rockridge Press (Publisher)
I get commissions for purchases made through links on this website. As an Amazon Associate I earn from qualifying purchases.