How has COVID-19 Affected Gout Management?

A new research study that has actually been released looking at this and it found that:

Here is the research study:

Healthcare gaps, psychological distress, and HRQoL deficits were commonly reported by people with gout throughout the COVID-19 pandemic.”

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Bestseller No. 1
Purge! Uric Acid Cleanse & Joint Support – Ready to Eat & Drink What You Want? – Active Mobility, Strong Flexibility, Healthy Inflammation – Tart Cherry & Celery Seed – 60 Vegetarian Soft Capsules
  • Joint comfort and detoxification promote healthy uric acid levels and maintain proper balance. You can have the confidence that every capsule has the strength and potency needed for uric acid support.
  • We blend all our products at a cGMP Certified Laboratory to ensure a contaminant-free product. We wouldn't have it any other way and neither should you.
  • Super ingredients rich in anthocyanins and antioxidants like Celery Seed and Tart Cherry Extract, Purge naturally promotes joint health, providing you with the best power to maintain comfort, flexibility, and mobility.
  • Pure natural formula in 100% vegetarian easy-to-swallow soft capsules, completely free of fillers, binders, and artificial ingredients. No gluten, wheat, or dairy. And of course, never tested on animals. Just a pure and tested product.
  • Try our products without worry with our 100% Happiness & Heath Commitment. We're confident that you will see results and be thrilled with your purchase. And through our Vitamin Angels 1-for-1 Match program, one bottle equals one year of vitamins for a child in need.
SaleBestseller No. 2
Uric Acid Cleanse with Tart Cherry 9600mg - Made in USA - Clinically Proven Natural Gоut Relief - Joint Comfort & Detoxification - Liquid Uric Acid Support Formula for High BioAvailability
  • Uric Acid Level Control - Concentrated Herbal Complex includes the right powerful mix of ingredients such as Tart Cherry & Celery Seed, which is clinically proven to support your healthy joints and uric acid balance in your system. This is the most efficient Uric Acid Level Control with 9600 mg Tart Cherry infused.
  • Max Absorption & Rapid Recovery - Our Uric Acid Cleanse with celery seed, as supporting ingredient, delivers potent anthocyanins to achieve joint comfort and recover muscles. The powerful combination provides joints with the ability to maintain comfort & flexibility naturally.
  • Strong Antioxidant Effect - The Unique Blend of Active Ingredients full of Vitamins & Trace Minerals, perfect for your health. Moreover, Polyphenols in Tart Cherry have more antioxidants than any other product. They protect your muscles from oxidative damage, support strength, and provide long-term wellness.
  • Pure Natural Formula - FairMile Organics is the most refined nutrition brand using zero fillers, binders, or artificial ingredients. We manufacture our product in the USA. Our tincture is gluten, wheat & dairy-free, and was never tested on animals.
  • Health Improvements & Satisfaction Guarantee - Be sure: you're fueling your body with the very best. We're confident that you will see results and be thrilled with your purchase. Otherwise, we are open to your proposals. Any of your questions will be resolved by professional customer service.
Bestseller No. 3
Uric Acid Support Supplement – Go-Out Tart Cherry Extract Capsules for SUSTAINED Relief, Improved Joint Health & Circulation with Celery Seed Extract, Turmeric, Bromelain by Mt. Angel Vitamins, 90-Ct.
  • LIVE LIVELY – Don’t let discomfort ruin your day. Ease joint pain and enjoy activities with Mt. Angel Vitamins! Go-Out uric acid cleanse provides sustained relief so you can get back on your feet!
  • IMPROVE & MOVE – Sick of stiffness? Help restore joint flexibility with black and tart cherry extract, celery seed extract, bromelain, and turmeric root. Go with go out capsules formulated with ingredients known to reduce inflammation.
  • GO WITH THE FLOW – By lowering uric acid levels, your go out relief capsules are known to fortify healthy circulation and blood pressure, protecting muscles and joints from damage.
  • SIMPLE SOLUTION – Enjoy a supplement that works with your schedule! To free yourself from pain, just take 1 of your 90 inflammation relief capsules twice daily. Support has never been so simple!
  • OUR PROMISE – At Mt. Angel Vitamins, we take pride in our capsules’ quality. We ensure your positive experience with restorative results from personally crafted and tested, non-GMO supplements!
Bestseller No. 4
Therapeutic Gout Relief Cream with Arnica Extract, Ilex Leaf Extract, Aloe Vera and Tea Tree Oil.
  • Immediate, Lasting & Quick Relief: Did you know that our unique pain relief cream is preferred by those dealing with inflammation, pain and discomfort related to flare-ups? Numerous All Natural pain relievers go to work to reduce inflammation, provide soothing relief and get you back on your feet!
  • Non-Greasy, Non-Staining & Fast Absorbing: Arnica gel cream with a refreshing mint scent. Within minutes, the cream is absorbed and the scent is vanished. Get back to your normal life!
  • Made In The USA: Manufactured and Packaged in the USA in a GMP Approved Facility for Purity and Potency
  • Natural Ingredients: Include Arnica Extract, Tea Tree Oil, Ilex Leaf Extract, Aloe, vitamins E & B6 and MSM.
  • Money Back Guarantee: We stand behind our Therapeutic Pain Relief Cream 100% and are sure you are going to love it! If you are less than 100% Satisfied with our product, for ANY reason, we will refund your money in full with no questions asked. What do you have to lose? Buy Now!
SaleBestseller No. 5
The Healing Gout Cookbook: Anti-Inflammatory Recipes to Lower Uric Acid Levels and Reduce Flares
  • Andrews MEd RD LD, Lisa Cicciarello (Author)
  • English (Publication Language)
  • 158 Pages - 03/31/2020 (Publication Date) - Rockridge Press (Publisher)
Bestseller No. 6
Urcinol - The Leading Uric Acid Supplement - 30 Day Supply. Premium Pain Relief & More Powerful Than Tart Cherry at Flushing Out Uric Acid.
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
Bestseller No. 7
NutriGout - Uric Acid Support Formula - 60 Vegetarian Capsules
  • Get Your Life Back - Sudden, severe pain caused by uric acid buildup strikes at the most unpredictable times. Take back control with NutriGout so you can do the things you love again
  • Stops Pain Before It Begins - Our uric acid supplement supports your kidneys and liver so that your body naturally flushes out excess uric acid before it gets out of control
  • All Natural Relief - Turmeric, Milk Thistle Extract, Bromelain, Celery Seed, Dandelion Extract and Chanca Piedra work synergistically, supporting normal, healthy UA levels
  • Made In The USA - Inspected in a GMP certified laboratory, our GMO-free formula contains no artificial colors or flavors. Powerful antioxidants can help restore joint flexibility, making it easier to rise out of bed in the morning and tackle your day
  • Need To Try It Before You Commit? We Guarantee your results, or your money back. So go ahead and click add to cart - your joints will thank you!
SaleBestseller No. 8
Uricel The Best Uric Acid Support Formula - High Potency Advanced Key Ingredients Designed to Support Healthy Uric Acid Levels with Tart Cherry, Celery Seed and More
  • TINGLE-FREE FEET & TOES. Uricel is a fast-acting herbal uric acid cleanse that helps balance uric acid levels to melt away the sharp tingling feeling in your feet and toes. By giving your body exactly what it needs to help expel the excess Uric acid which causes discomfort, the body can then do what it does best by helping return you get back to your normal self.
  • CLEANSE AND FLUSH URIC ACID and uric acid crystals that aggravate your feet, toes, and joints. Uricel is an herbal blend of Tart Cherry, Chanca Piedra, and Celery Seed that helps balance uric acid levels to target swelling and avoid future flare-ups. Our customers are constantly amazed by just how fast their discomfort in their feet, toes, and other affected joints melts away. Uricel is designed to help you regain your mobility and continue with your daily routines as quickly as possible.
  • SUPPORTS HEALTHY KIDNEYS, TOO. Purine content from diet and alcohol can form uric acid crystals that are difficult for your kidneys to pass. Chanca Piedrea translates to “stone breaker,” and Celery Seed is a mild diuretic that boosts urine flow to get uric acid moving out of the body and support healthy kidneys.
  • CAPSULES NEED TO BE DIGESTED, LIQUIDS DON’T. Have you ever seen a pill in nature? Neither have we, and frankly, we're tired of the nasty burps and eye-watering gulps. Liquids don't need to travel to your stomach before they start absorbing, liquids are immediately bioavailable and work fast! Not to mention, our alcohol-free tinctures taste great, and they're safe for kids, too.
  • CRAFTED UNDER THE GUIDANCE OF A TRAINED HERBALIST IN THE USA. Instead of cramming all these ingredients in a capsule that was thrown together somewhere in China, Uricel is made and manufactured in the USA. Each batch is 3rd-party tested for safety and purity so you only get the best.
Bestseller No. 9
Gout Complete 16oz - Natural & Organic Liquid Gout Treatment, Uric Acid Flush & Remedy Support Medicine (W/Tart Cherry)
  • WHY USE A LIQUID TREATMENT? – Research indicates that liquid supplements are more easily absorbed into the body. With an average absorption rate of better than 90% vs. pills at 10-15%, doesn’t it make sense that a liquid can control uric acid better and is the best alternative? Pills using the best of ingredients are simply less effective for relief.
  • PROVEN RESULTS – As a naturopathic remedy using only natural and organic ingredients, we addressed the root causes of uric acid buildup, kidney function and circulation. With proven ingredients that address kidney function, inflammation, pain, circulation, and many other health specific issues that take place to create the imbalance of uric acid in the body, these natural remedies are for you. Uric Acid Complete is used both during the course of an attack and as a preventative measure.
  • A COMPLETE ALTERNATIVE – With both Organic and Kosher certifications, we use only the highest concentration and quality of ingredients. We use more than 35 ingredients, 3 times more than any comparable product, to help reduce inflammation, increase circulation, cleanse and flush out infection, and rebalance Ph, mineral and uric acid levels. With our 100% SATISFACTION GUARANTEE, you can feel safe that you are making the best choice in a proven and natural uric acid reducer.
  • MADE IN THE USA! USDA Organic and OU Kosher Certified.
Bestseller No. 10
The 28-Day Gout Diet Plan: The Optimal Nutrition Guide to Manage Gout
  • Kamveris MS RD LDN, Sophia (Author)
  • English (Publication Language)
  • 194 Pages - 02/05/2019 (Publication Date) - Rockridge Press (Publisher)

I get commissions for purchases made through links on this website. As an Amazon Associate I earn from qualifying purchases.

Colchicine, a common drug to treat gout, is being evaluated to treat COVID-19 and shows significant reduction in inflammation and lung injury in pre-clinical studies

Death in COVID-19 patients has actually been linked to the cytokine storm, where the body produces excessive pro-inflammatory particles (cytokines) that ultimately lead to ARDS and potentially death. Full research study outcomes are readily available in preprint and support the continuation of the COLCORONA trial.

The double-blind, placebo-controlled, randomized COLCORONA trial featuring a generic immunomodulator (colchicine) passed its futility analysis in June 2020 with an independent Data Safety Monitoring Board, enabling continued enrollment. Colchicine, which is already available for treatment of gout, pericarditis, and Familial Mediterranean Fever, would be a cost effective orally administered treatment alternative if outcomes prove positive..

Unlike most other research studies, this research study does not include leaving your house. The study staff will call you straight via phone or video-visits for follow-up. Medication or a placebo (a pill without any active components) will be provided to your house at no cost.If you have an interest in signing up with, the study personnel will figure out if you are eligible to join. This research study is among the couple of registering newly detected patients with moderate to moderate signs who are not hospitalized and over the age of 40 (and hires clients past the age of 70). Involvement in the research study lasts 30 days. When the research study is completed, the results will be announced, however will not include your recognizing information.Patients and physicians thinking about COLCORONA can call the research study hotline at 1-877-536-6837, 24/7 or visit www.colcorona.net. If you have actually recently been detected with COVID-19 and you are interested in taking part in the COLCORONA trial, do not postpone calling the hotline number.

The COLCORONA trial hires recently diagnosed, non-hospitalized adult clients with COVID-19 for participation in a totally free, at-home clinical trial developed to minimally problem patients. Full research study outcomes are available in preprint and support the extension of the COLCORONA trial.

What Patients Need to Know About the COLCORONA Trial to Enroll.

” At the minute, there is no readily available, FDA-approved treatment that can be provided to patients in your home to avoid them from getting worse health problem, hospitalization and death from COVID-19 problems. It is extremely crucial for us to discover therapies that we can provide to clients now,” stated Dr. Norman Lepor, Director of Clinical Research for Westside Medical Associates of Los Angeles and COLCORONA main investigator for Los Angeles.

About the COLCORONA Trial.

Unlike many other research studies, this study does not involve leaving your home. If you have actually recently been detected with COVID-19 and you are interested in getting involved in the COLCORONA trial, do not delay calling the hotline number.

MONTREAL, July 27, 2020 / PRNewswire/– Montreal Heart Institute (MHI) today revealed that the COLCORONA scientific trial has actually increased registration capability in the United States ( Los Angeles, San Francisco, Houston, Dallas, Miami, Gainesville, New York, New Jersey, Connecticut) as the favorable case numbers of COVID-19 continue to rise. The COLCORONA trial hires recently diagnosed, non-hospitalized adult patients with COVID-19 for participation in a free, at-home clinical trial created to minimally burden clients. The largest trial of its kind, this at-home, contactless trial continues to likewise register in Canada, Spain and South Africa with more sites constantly added.

” Our current lead to pre-clinical research studies reveal the capacity of colchicine to minimize the inflammatory storm and lung damage likewise seen in clients with COVID-19,” said Dr. Jean-Claude Tardif, Director of the Research Center at MHI, Professor of Medicine at the University of Montreal, and COLCORONA principal detective. “We are dedicated to consisting of a large number of patients worldwide in this robust research study to determine the capability of colchicine to keep clients out of the healthcare facility, off ventilators and ultimately save lives.”

COLCORONA is a contact-free, at-home, randomized, double-blind, placebo-controlled study lack numerous areas in Canada, the United States, Europe, South America, and South Africa. COLCORONA is collaborated by the Montreal Health Innovations Coordinating Center (MHICC) and moneyed by the Government of Quebec, the Bill & & Melinda Gates Foundation, the National Heart, Lung, and Blood Institute (NHLBI) of the United States National Institutes of Health (NIH), and Sophie Desmarais Montréal benefactor, daughter of the late company mogul, Paul Desmarais Sr., Pharmascience, CGI, and DACIMA are likewise collaborators of COLCORONA.

To learn more about the study, go to www.colcorona.net.

Advertisement:

Bestseller No. 1
Purge! Uric Acid Cleanse & Joint Support – Ready to Eat & Drink What You Want? – Active Mobility, Strong Flexibility, Healthy Inflammation – Tart Cherry & Celery Seed – 60 Vegetarian Soft Capsules
  • Joint comfort and detoxification promote healthy uric acid levels and maintain proper balance. You can have the confidence that every capsule has the strength and potency needed for uric acid support.
  • We blend all our products at a cGMP Certified Laboratory to ensure a contaminant-free product. We wouldn't have it any other way and neither should you.
  • Super ingredients rich in anthocyanins and antioxidants like Celery Seed and Tart Cherry Extract, Purge naturally promotes joint health, providing you with the best power to maintain comfort, flexibility, and mobility.
  • Pure natural formula in 100% vegetarian easy-to-swallow soft capsules, completely free of fillers, binders, and artificial ingredients. No gluten, wheat, or dairy. And of course, never tested on animals. Just a pure and tested product.
  • Try our products without worry with our 100% Happiness & Heath Commitment. We're confident that you will see results and be thrilled with your purchase. And through our Vitamin Angels 1-for-1 Match program, one bottle equals one year of vitamins for a child in need.
SaleBestseller No. 2
Uric Acid Cleanse with Tart Cherry 9600mg - Made in USA - Clinically Proven Natural Gоut Relief - Joint Comfort & Detoxification - Liquid Uric Acid Support Formula for High BioAvailability
  • Uric Acid Level Control - Concentrated Herbal Complex includes the right powerful mix of ingredients such as Tart Cherry & Celery Seed, which is clinically proven to support your healthy joints and uric acid balance in your system. This is the most efficient Uric Acid Level Control with 9600 mg Tart Cherry infused.
  • Max Absorption & Rapid Recovery - Our Uric Acid Cleanse with celery seed, as supporting ingredient, delivers potent anthocyanins to achieve joint comfort and recover muscles. The powerful combination provides joints with the ability to maintain comfort & flexibility naturally.
  • Strong Antioxidant Effect - The Unique Blend of Active Ingredients full of Vitamins & Trace Minerals, perfect for your health. Moreover, Polyphenols in Tart Cherry have more antioxidants than any other product. They protect your muscles from oxidative damage, support strength, and provide long-term wellness.
  • Pure Natural Formula - FairMile Organics is the most refined nutrition brand using zero fillers, binders, or artificial ingredients. We manufacture our product in the USA. Our tincture is gluten, wheat & dairy-free, and was never tested on animals.
  • Health Improvements & Satisfaction Guarantee - Be sure: you're fueling your body with the very best. We're confident that you will see results and be thrilled with your purchase. Otherwise, we are open to your proposals. Any of your questions will be resolved by professional customer service.
Bestseller No. 3
Uric Acid Support Supplement – Go-Out Tart Cherry Extract Capsules for SUSTAINED Relief, Improved Joint Health & Circulation with Celery Seed Extract, Turmeric, Bromelain by Mt. Angel Vitamins, 90-Ct.
  • LIVE LIVELY – Don’t let discomfort ruin your day. Ease joint pain and enjoy activities with Mt. Angel Vitamins! Go-Out uric acid cleanse provides sustained relief so you can get back on your feet!
  • IMPROVE & MOVE – Sick of stiffness? Help restore joint flexibility with black and tart cherry extract, celery seed extract, bromelain, and turmeric root. Go with go out capsules formulated with ingredients known to reduce inflammation.
  • GO WITH THE FLOW – By lowering uric acid levels, your go out relief capsules are known to fortify healthy circulation and blood pressure, protecting muscles and joints from damage.
  • SIMPLE SOLUTION – Enjoy a supplement that works with your schedule! To free yourself from pain, just take 1 of your 90 inflammation relief capsules twice daily. Support has never been so simple!
  • OUR PROMISE – At Mt. Angel Vitamins, we take pride in our capsules’ quality. We ensure your positive experience with restorative results from personally crafted and tested, non-GMO supplements!
Bestseller No. 4
Therapeutic Gout Relief Cream with Arnica Extract, Ilex Leaf Extract, Aloe Vera and Tea Tree Oil.
  • Immediate, Lasting & Quick Relief: Did you know that our unique pain relief cream is preferred by those dealing with inflammation, pain and discomfort related to flare-ups? Numerous All Natural pain relievers go to work to reduce inflammation, provide soothing relief and get you back on your feet!
  • Non-Greasy, Non-Staining & Fast Absorbing: Arnica gel cream with a refreshing mint scent. Within minutes, the cream is absorbed and the scent is vanished. Get back to your normal life!
  • Made In The USA: Manufactured and Packaged in the USA in a GMP Approved Facility for Purity and Potency
  • Natural Ingredients: Include Arnica Extract, Tea Tree Oil, Ilex Leaf Extract, Aloe, vitamins E & B6 and MSM.
  • Money Back Guarantee: We stand behind our Therapeutic Pain Relief Cream 100% and are sure you are going to love it! If you are less than 100% Satisfied with our product, for ANY reason, we will refund your money in full with no questions asked. What do you have to lose? Buy Now!
SaleBestseller No. 5
The Healing Gout Cookbook: Anti-Inflammatory Recipes to Lower Uric Acid Levels and Reduce Flares
  • Andrews MEd RD LD, Lisa Cicciarello (Author)
  • English (Publication Language)
  • 158 Pages - 03/31/2020 (Publication Date) - Rockridge Press (Publisher)
Bestseller No. 6
Urcinol - The Leading Uric Acid Supplement - 30 Day Supply. Premium Pain Relief & More Powerful Than Tart Cherry at Flushing Out Uric Acid.
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
Bestseller No. 7
NutriGout - Uric Acid Support Formula - 60 Vegetarian Capsules
  • Get Your Life Back - Sudden, severe pain caused by uric acid buildup strikes at the most unpredictable times. Take back control with NutriGout so you can do the things you love again
  • Stops Pain Before It Begins - Our uric acid supplement supports your kidneys and liver so that your body naturally flushes out excess uric acid before it gets out of control
  • All Natural Relief - Turmeric, Milk Thistle Extract, Bromelain, Celery Seed, Dandelion Extract and Chanca Piedra work synergistically, supporting normal, healthy UA levels
  • Made In The USA - Inspected in a GMP certified laboratory, our GMO-free formula contains no artificial colors or flavors. Powerful antioxidants can help restore joint flexibility, making it easier to rise out of bed in the morning and tackle your day
  • Need To Try It Before You Commit? We Guarantee your results, or your money back. So go ahead and click add to cart - your joints will thank you!
SaleBestseller No. 8
Uricel The Best Uric Acid Support Formula - High Potency Advanced Key Ingredients Designed to Support Healthy Uric Acid Levels with Tart Cherry, Celery Seed and More
  • TINGLE-FREE FEET & TOES. Uricel is a fast-acting herbal uric acid cleanse that helps balance uric acid levels to melt away the sharp tingling feeling in your feet and toes. By giving your body exactly what it needs to help expel the excess Uric acid which causes discomfort, the body can then do what it does best by helping return you get back to your normal self.
  • CLEANSE AND FLUSH URIC ACID and uric acid crystals that aggravate your feet, toes, and joints. Uricel is an herbal blend of Tart Cherry, Chanca Piedra, and Celery Seed that helps balance uric acid levels to target swelling and avoid future flare-ups. Our customers are constantly amazed by just how fast their discomfort in their feet, toes, and other affected joints melts away. Uricel is designed to help you regain your mobility and continue with your daily routines as quickly as possible.
  • SUPPORTS HEALTHY KIDNEYS, TOO. Purine content from diet and alcohol can form uric acid crystals that are difficult for your kidneys to pass. Chanca Piedrea translates to “stone breaker,” and Celery Seed is a mild diuretic that boosts urine flow to get uric acid moving out of the body and support healthy kidneys.
  • CAPSULES NEED TO BE DIGESTED, LIQUIDS DON’T. Have you ever seen a pill in nature? Neither have we, and frankly, we're tired of the nasty burps and eye-watering gulps. Liquids don't need to travel to your stomach before they start absorbing, liquids are immediately bioavailable and work fast! Not to mention, our alcohol-free tinctures taste great, and they're safe for kids, too.
  • CRAFTED UNDER THE GUIDANCE OF A TRAINED HERBALIST IN THE USA. Instead of cramming all these ingredients in a capsule that was thrown together somewhere in China, Uricel is made and manufactured in the USA. Each batch is 3rd-party tested for safety and purity so you only get the best.
Bestseller No. 9
Gout Complete 16oz - Natural & Organic Liquid Gout Treatment, Uric Acid Flush & Remedy Support Medicine (W/Tart Cherry)
  • WHY USE A LIQUID TREATMENT? – Research indicates that liquid supplements are more easily absorbed into the body. With an average absorption rate of better than 90% vs. pills at 10-15%, doesn’t it make sense that a liquid can control uric acid better and is the best alternative? Pills using the best of ingredients are simply less effective for relief.
  • PROVEN RESULTS – As a naturopathic remedy using only natural and organic ingredients, we addressed the root causes of uric acid buildup, kidney function and circulation. With proven ingredients that address kidney function, inflammation, pain, circulation, and many other health specific issues that take place to create the imbalance of uric acid in the body, these natural remedies are for you. Uric Acid Complete is used both during the course of an attack and as a preventative measure.
  • A COMPLETE ALTERNATIVE – With both Organic and Kosher certifications, we use only the highest concentration and quality of ingredients. We use more than 35 ingredients, 3 times more than any comparable product, to help reduce inflammation, increase circulation, cleanse and flush out infection, and rebalance Ph, mineral and uric acid levels. With our 100% SATISFACTION GUARANTEE, you can feel safe that you are making the best choice in a proven and natural uric acid reducer.
  • MADE IN THE USA! USDA Organic and OU Kosher Certified.
Bestseller No. 10
The 28-Day Gout Diet Plan: The Optimal Nutrition Guide to Manage Gout
  • Kamveris MS RD LDN, Sophia (Author)
  • English (Publication Language)
  • 194 Pages - 02/05/2019 (Publication Date) - Rockridge Press (Publisher)

I get commissions for purchases made through links on this website. As an Amazon Associate I earn from qualifying purchases.

Revive Therapeutics Explores the Use of Bucillamine as a Novel Treatment for Infectious Diseases including COVID-19

” Revive was founded on the facility of finding brand-new uses for known drugs, and we are broadening on our rich item portfolio to target transmittable diseases such as the coronavirus illness or COVID-19,” stated Michael Frank, Revives Chief Executive Officer. “Revive has a history in the medical advancement with Bucillamine in the treatment of intense gout flares and cystinuria, and we will advance our efforts in restoring and checking out new usages of Bucillamine for unmet medical requirements.”

TORONTO, March 20, 2020 (WORLD NEWSWIRE)– Revive Therapies Ltd. (” Revive” or the “Business”) (CSE: RVV), a life sciences business, is delighted to reveal that it is checking out making use of the drug Bucillamine as a prospective novel treatment for contagious diseases including influenza and the coronavirus illness (COVID-19). The Business has actually requested a provisionary patent with the U.S. Patent and Trademark Office entitled “Use of Bucillamine in the Treatment of Contagious Diseases” (Serial No. 62/991,996).

Restore has explored making use of Bucillamine in the treatment of severe gout flares and has completed a Phase 2 research study in the U.S. under its Investigational New Drug (” IND”) application that was accepted by the U.S. Food and Drug Administration (” FDA”). The Company checked out the usage of Bucillamine in the treatment of cystinuria where it has actually received FDA orphan drug status and its IND was accepted by the FDA to perform a Phase 2 research study in the U.S.

Scientific Rationale for the Investigation reasoning Bucillamine to Treat Infectious Diseases including Influenza transmittable COVID-19

Bucillamine (N-( mercapto-2-methylpropionyl)- l-cysteine), which has a widely known security profile and is recommended in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years, is a cysteine derivative with 2 thiol groups that is 16-fold more powerful than NAC as a thiol donor in vivo, providing it greatly remarkable function in bring back glutathione and for that reason greater potential to avoid intense lung injury during influenza infection.8 Bucillamine has also been shown to avoid oxidative and reperfusion injury in heart and liver tissues8 and is extremely cell permeable for effective shipment into cells.8,9 Bucillamine has unrealized potential for the treatment of influenza with both proven safety and tested system of action similar to that of NAC, but with much higher effectiveness, reducing the previous barriers to utilizing thiols therapeutically. It is likewise sensible to hypothesize that comparable processes connected to ROS are involved in severe lung injury throughout nCov-19 infection, potentially justifying the investigation of bucillamine as an intervention for COVID-19.

Revive is establishing an item and scientific advancement strategy intending to unlock the complete capacity of Bucillamine. The Company will announce its initiatives as they unfold.

Current antiviral interventions for influenza have actually displayed modest efficacy, particularly in improving death in at-risk populations, such as the elderly.1,2 Novel antivirals have actually been pestered by poor oral bioavailability and lack of efficacy when not provided early.1 This is since these drugs mostly act to prevent the early processes of virus binding to cells or viral duplication.2 Thiols, especially N-acetylcysteine (NAC), with antioxidant and lowering activity have been examined as reliable treatments that abrogate the capacity for influenza to cause severe illness.3,4,5 Restoration of glutathione, the major intracellular thiol antioxidant, is a vital functional activity of NAC.6 Reactive oxygen types (ROS) generation during influenza virus infection worsen harmful inflammation and configured death of epithelial cells.7 Studies in human cells and animal designs have revealed that NAC works to prevent severe lung injury brought on by influenza virus infection through inhibition of these ROS-mediated systems.4,7 NAC has actually been examined scientifically and found to significantly attenuate medical signs connected with influenza infection, specifically in elderly at-risk patients.5 While NAC is quickly used up by cells and has low toxicity, scientific efficacy has actually required long-term and high-dose administration since of modest relative effectiveness, limiting its clinical applicability.

Revive is a company focused on the research, advancement and commercialization of unique psychedelic and cannabinoid-based life sciences products and drug repurposing for infectious illness. With its recent acquisition of Psilocin Pharma Corp., Revive will advance Psilocybin-based therapies in various diseases and disorders and will focus on advancement efforts to take benefit of several regulatory rewards awarded by the FDA such as Orphan Drug, Fast Track, Breakthrough Therapy and Rare Pediatric Disease classifications. The Company is likewise checking out the usage of Bucillamine for the potential treatment of infectious illness.

Referrals

1. Muthuri SG, Venkatesan S, Myles PR et al. Effectiveness of neuraminidase inhibitors in minimizing mortality in patients confessed to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of private participant data Lancet Respir Med. 2014 May; 2( 5 ):395 -404. doi: 10.1016/ S2213-2600( 14 )70041-4.

2. Duwe S. Influenza infections– antiviral therapy and resistance.

3. Zhang RH, Li CH, Wang CL et al. N-acetyl-l-cystine( NAC) secures versus H9N2 swine influenza virus-induced acute lung injury. Int Immunopharmacol. 2014 Sep; 22( 1 ):1 -8. doi: 10.1016/ j.intimp.2014.06.013.

Ungheri D, Pisani C, Sanson G et al. Protective impact of n-acetylcysteine in a model of influenza infection in mice.

5. De Flora S, Grassi C, and Carati L. Attenuation of influenza-like symptomatology and enhancement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J 1997; 10: 1535– 1541 DOI: 10.1183/ 09031936.97.10071535.

The Basics of Thiols and Cysteines in Redox Biology and Chemistry. Free Radic Biol Med. 2015 Mar; 0: 148– 157.

7. Mata M, Morcillo E, Gimeno C, Cortijo J. N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory conciliators in alveolar type II epithelial cells contaminated with influenza infection A and B and with respiratory syncytial infection (RSV). Biochem Pharmacol. 2011 Sep 1; 82( 5 ):548 -55. doi: 10.1016/ j.bcp.2011.05.014.

Bucillamine: a potent thiol donor with several clinical applications. Cardiovasc Drug Rev. 2003 Summer; 21( 2 ):77 -90.

9. Sagawa A, Fujisaku A, Ohnishi K et al. A multicentre trial of bucillamine in the treatment of early rheumatoid arthritis (SNOW study). Mod Rheumatol. 2011 Jun; 21( 3 ):251 -7. doi: 10.1007/ s10165-010-0385-4.

Restore is a business focused on the research study, advancement and commercialization of novel psychedelic and cannabinoid-based life sciences items and drug repurposing for transmittable illness. Restores technology is being advanced to fill the medical needs for disorders and illness such as discomfort, inflammation, and injury care. Revives cannabinoid pharmaceutical portfolio focuses on unusual inflammatory locations such as liver illness. With its recent acquisition of Psilocin Pharma Corp., Revive will advance Psilocybin-based therapeutics in various diseases and conditions and will focus on development efforts to take advantage of several regulative incentives awarded by the FDA such as Orphan Drug, Fast Track, Breakthrough Therapy and Rare Pediatric Disease designations. The Company is also checking out the use of Bucillamine for the prospective treatment of infectious illness.

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Purge! Uric Acid Cleanse & Joint Support – Ready to Eat & Drink What You Want? – Active Mobility, Strong Flexibility, Healthy Inflammation – Tart Cherry & Celery Seed – 60 Vegetarian Soft Capsules
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Uric Acid Cleanse with Tart Cherry 9600mg - Made in USA - Clinically Proven Natural Gоut Relief - Joint Comfort & Detoxification - Liquid Uric Acid Support Formula for High BioAvailability
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SaleBestseller No. 5
The Healing Gout Cookbook: Anti-Inflammatory Recipes to Lower Uric Acid Levels and Reduce Flares
  • Andrews MEd RD LD, Lisa Cicciarello (Author)
  • English (Publication Language)
  • 158 Pages - 03/31/2020 (Publication Date) - Rockridge Press (Publisher)
Bestseller No. 6
Urcinol - The Leading Uric Acid Supplement - 30 Day Supply. Premium Pain Relief & More Powerful Than Tart Cherry at Flushing Out Uric Acid.
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
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NutriGout - Uric Acid Support Formula - 60 Vegetarian Capsules
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SaleBestseller No. 8
Uricel The Best Uric Acid Support Formula - High Potency Advanced Key Ingredients Designed to Support Healthy Uric Acid Levels with Tart Cherry, Celery Seed and More
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Bestseller No. 9
Gout Complete 16oz - Natural & Organic Liquid Gout Treatment, Uric Acid Flush & Remedy Support Medicine (W/Tart Cherry)
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Bestseller No. 10
The 28-Day Gout Diet Plan: The Optimal Nutrition Guide to Manage Gout
  • Kamveris MS RD LDN, Sophia (Author)
  • English (Publication Language)
  • 194 Pages - 02/05/2019 (Publication Date) - Rockridge Press (Publisher)

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